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Ensure its not prone to freezing in the back, and use a thermometer to periodically check its accuracy

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These enzymes are involved in detoxification processes 25 by linking toxic compounds with glutathione (GSH), a key antioxidant non-protein thiol, thus counteracting oxidative stress 26

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Persistent constipation : If you have not had a bowel movement for more than 34 days despite dietary measures and over-the-counter laxatives, or if you experience severe abdominal distension, this warrants assessment for possible bowel obstruction